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Can CBD make you more anxious?

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Note: This CBD Benefits Guide has been co-authored by Dr Andres Maldonado MD, in line with the 'Vape and Juice Medical Review Policy'. See our Medical Editorial Team.

TL:DR | Typically, cannabis can increase angst sensations, it is thought of something that makes users more anxious. Common cannabis induced symptoms can cause panic attacks, OCD, delirium and a rise in heart rate in certain people, particularly when too much is taken. With CBD’s close connection to cannabis, you might be wondering can CBD make you more anxious?

In this article, we are going to point you in the direction of some research that should hopefully answer your worries. 

Can CBD make you more or less anxious

Research shows that CBD should make you less anxious, not increase it

We found that existing preclinical evidence strongly supports CBD as a treatment for generalized anxiety disorder, panic disorder, social anxiety disorder, obsessive-compulsive disorder, and post-traumatic stress disorder when administered acutely; however, few studies have investigated chronic CBD dosing [1]

There have been several studies into CBD for anxiety which answers the question can CBD make you more anxious?

Studies have looked at how the cannabinoid can help humans feel less anxious during events like public speaking. The double blind, placebo controlled studies, have been promising. [2]

Other studies have shown to reduce stress and lower signs of the disorder in rats. [3]

Relief from symptoms caused by the condition is one of the leading reasons why people choose to use the cannabinoid. Our customers report that it makes them feel calm, clear headed and helps them to sleep better. 

None of the studies have found the cannabinoid to be the cause or to heighten symptoms.

Dosing of cannabinoids - do they make you more anxious?

Would CBD make you more anxious?

Generally, the side effects of CBD do not include heart fluttering, feelings of dread, overthinking or panic that goes alongside the condition. Instead, it may alleviate these feelings. 

The hemp based oil may leave you feeling calmer even during stressful situations that would usually lead to feelings of panic or unease.

You might have made the connection as to weather CBD could make you more anxious because cannabis can induce and heighten the feelings. However, this is due to high levels of THC in cannabis. The side effects of taking THC are very different to CBD, which is why the latter remains legal.

If you are taking CBD using a vaporiser and have added nicotine to it then this not only degrades the cannabinoid, but may also make you feel jittery. This would be due to the nicotine, not the CBD. If you decide to vaporise the cannabinoid then always make sure you do not nicotine and you keep a separate tank for nicotine juices so that you do not cause any contamination.

CBD isn’t 100% risk free, however the risks are rare and only at high doses. Doses higher than recommended for humans. Here’s something we found on rare CBD risks when taking too much:

CBD is not risk-free. In animals, CBD AEs included developmental toxicity, embryo-fetal mortality, central nervous system inhibition and neurotoxicity, hepatocellular injuries, spermatogenesis reduction, organ weight alterations, male reproductive system alterations, and hypotension, although at doses higher than recommended for human pharmacotherapies. Human CBD studies for epilepsy and psychiatric disorders reported CBD-induced drug-drug interactions, hepatic abnormalities, diarrhea, fatigue, vomiting, and somnolence [4]


CBD is making me more anxious, what do I do?

Firstly, you should check that you are taking cannabidiol which contains legal limits of THC. In the UK these limits are less than 0.2%. You would only find THC in full spectrum CBD, so if taking THC is something you are concerned about then switch to isolate or broad spectrum.  Or, you could of course, seek medical help.

Next you might lower your dosage. Everyone has a different tolerance to the cannabinoid and you will need to work out what is right for you. We always suggest that you start with a lower dose and mg to see how it affects you personally. 

cbd make you more anxious?

Final thoughts 

If you are concerned as to whether or not "can CBD make you more anxious?" you should read through some of the studies below. They can be quite science heavy, but the conclusions and summaries are often good if you’re not into reading in depth content with some pretty long words!

Another way to understand more about the condition and how this cannabinoid may help is to chat with others who use it. This can give you real life stories and experience, as well as an insight into how it may help you.

You might also try a lower dose of the cannabinoid to see how you react to it. You can always increase your dosage or switch between full or broad spectrum and isolate. 

Everyone has their own sweet spot, you just need to find yours.

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References

[1] Blessing EM, Steenkamp MM, Manzanares J, Marmar CR. Cannabidiol as a Potential Treatment for Anxiety Disorders. Neurotherapeutics. 2015 Oct;12(4):825-36. doi: 10.1007/s13311-015-0387-1. PMID: 26341731; PMCID: PMC4604171.

[2] Bergamaschi MM, Queiroz RH, Chagas MH, et al. Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients. Neuropsychopharmacology. 2011;36(6):1219-1226. doi:10.1038/npp.2011.6

[3] Zieba J, Sinclair D, Sebree T, et al. Cannabidiol (CBD) reduces anxiety-related behavior in mice via an FMRP-independent mechanism. Pharmacol Biochem Behav. 2019;181:93-100. doi:10.1016/j.pbb.2019.05.002

[4] Huestis MA, Solimini R, Pichini S, Pacifici R, Carlier J, Busardò FP. Cannabidiol Adverse Effects and Toxicity. Curr Neuropharmacol. 2019;17(10):974-989. doi:10.2174/1570159X17666190603171901

David Mason | Founder Vape and Juice

Founder of 'Vape and Juice' - I began vaping in 2009 and have blogged here since 2013. When I'm not providing average vape advice I can be found on Vape and Juice TV or running the No.1 Vape News Podcast - Cotton and Kanthal. Fan of cats and 6mg Heisenberg.

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